The phone comes with a 6.43-inch touchscreen display with a resolution of 1080×2400 pixels. Redmi Note 10S is powered by an octa-core MediaTek Helio G95 processor. It comes with 8GB of RAM. The Redmi Note 10S runs Android 11 and is powered by a 5000mAh battery. The Redmi Note 10S supports proprietary fast charging.

As far as the cameras are concerned, the Redmi Note 10S on the rear packs a 64-megapixel primary camera with an f/1.8 aperture; an 8-megapixel camera with an f/2.2 aperture; a 2-megapixel camera with an f/2.4 aperture, and a 2-megapixel camera with an f/2.4 aperture. The rear camera setup has autofocus. It sports a 13-megapixel camera on the front for selfies with an f/2. 5 aperture.

The Redmi Note 10S runs MIUI 12.5 is based on Android 11 and packs 128GB of inbuilt storage that can be expanded via microSD card (up to 512GB) with a dedicated slot. The Redmi Note 10S is a dual-SIM (GSM and GSM) smartphone that accepts Nano-SIM and Nano-SIM cards.

Connectivity options on the Redmi Note 10S include Wi-Fi, GPS, Bluetooth v5.0, NFC, Infrared, USB Type-C, 3G, and 4G (with support for Band 40 used by some LTE networks in India). Sensors on the phone include fingerprint sensor